Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters
- 作者：Sandham ; David A. ; Barker ; Lucy ; Beattie ; David ; Beer ; David ; Bidlake ; Louise ; Bentley ; David ; et. al.
- 关键词：Glucocorticoids ; Asthma ; Duration of action ; Side effects
- 刊名：Bioorganic and Medicinal Chemistry
- 出版年：2004
- 期刊代码：9_09680896
- 类别：ch
- 出版时间：October 1, 2004
- 卷：12
- 期：19
- 页码：5213-5224
- 文件大小：410 K
摘要
A series of novel corticosteroid derivatives featuring C-17 furoate ester functionality have been synthesised. Profiling in vitro and in vivo has resulted in the identification of a compound with a longer duration of action and a lower oral side effect profile in rodents compared to budesonide.