- 作者：Maria E. Barnes ; Maria.Barnes@mssm.edu ; David Gozal ; Dennis L. Molfese
- 关键词：A/EF ; attention/executive functioning domain ; ADHD ; attention deficit/hyperactivity disorder ; AHI ; apnoea hypopnea index ; ANOVA ; analysis of variance ; AT ; adenotonsillectomy ; BMI ; body mass index ; CBCL ; Child Behaviour Checklist ; CSI-4 ; Childhood Symptom
- 刊名：Sleep Medicine
- 出版年：2012
- 期刊代码：241_13899457
- 类别：med
- 出版时间：April, 2012
- 卷：13
- 期：4
- 页码：368-377
- 文件大小：1298 K
class="h4">Background
Obstructive sleep apnoea (OSA) in children has been causally implicated in neurobehavioural and cognitive dysfunction. Consequently, the American Academy of Paediatrics highlighted the need to study pertinent functional cognitive outcomes before and after treatment. However, neurocognitive function has thus far only been assessed by caregiver-completed questionnaires, which can be labour intensive and time consuming, such that the need for complementary and more objective measures has emerged.class="h4">Objective
The study aimed to identify electrophysiological correlates of neurocognitive alterations in children with OSA and investigate utility as a predictive tool.
class="h4">Patients and methods
Twenty-eight children (14 OSA and 14 matched controls) underwent overnight sleep studies and neurocognitive testing, as well as the oddball attention task while event-related potentials (ERPs) were recorded. ERPs were analysed using temporal principal components and source analyses that provided dependent variables for the subsequent repeated measures analysis of variance (ANOVA) and multiple regressions. Time-locked waveforms formed spatial models that localised electrical activity in the brain. ERP differences between groups were then correlated to neurocognitive outcomes.
class="h4">Results
OSA children exhibited significantly altered ERP patterns of neural activation and impaired neurocognitive performance. Specific ERP variables exhibited accurate predictive ability regarding performance on neurobehavioural measures.
class="h4">Conclusion
Specific ERP events during a single attention task can reliably identify the presence of OSA-associated cognitive dysfunction. Electrophysiological approaches during specific cognitive tasks may serve as simple, complementary, and reliable reporters of cognitive dysfunction associated with OSA in children.