Effects of Type II diabetes on muscle microvascular oxygen pressures
- 作者：Danielle J. Padilla ; Paul McDonough ; Brad J. Behnke ; Yutaka Kano ; K. Sue Hageman ; Timothy I. Musch ; David C. Poole
- 关键词：none ; color ; black" href="/science?_ob=MathURL&_method=retrieve&_udi=B6X16-4KRNR35-1&_mathId=mml35&_user=10&_cdi=7234&_rdoc=12&_acct=C000050221&_version=1&_userid=10&md5=47f4dda6327f1a16a797a23ea46f3649" title="Cli
- 刊名：Respiratory Physiology & Neurobiology
- 出版年：2007
- 期刊代码：185_15699048
- 类别：bio
- 出版时间：14 May 2007
- 卷：156
- 期：2
- 页码：187-195
- 文件大小：425 K
摘要
We tested the hypothesis that muscle microvascular O2 pressure (PmvO2; reflecting the O2 delivery to O2 uptake ratio) would be lowered in the spinotrapezius muscle of Goto–Kakizaki (GK) Type II diabetic rats (n = 7) at rest and during twitch contractions when compared to control (CON; n = 5) rats. At rest, PmvO2 was lower in GK versus CON rats (CON: 29 ± 2; GK: 18 ± 2 Torr; P < 0.05). At the onset of contractions, GK rats evidenced a faster change in PmvO2 than CON (i.e., time constant (τ); CON: 16 ± 4; GK: 6 ± 2 s; P < 0.05). In contrast to the monoexponential fall in PmvO2 to the steady-state level seen in CON, GK rats exhibited a biphasic PmvO2 response that included a blunted (or non-existent) PmvO2 decrease followed by recovery to a steady-state PmvO2 that was at, or slightly above, resting values. Compared with CON, this decreased PmvO2 across the transition to a higher metabolic rate in Type II diabetes would be expected to impair blood-muscle O2 exchange and contractile function.