GABA_A-receptor assembly in vivo: lessons from subunit mutant mice

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• 作者：Mohler ; H. ; Luscher ; B. ; Fritschy ; J.-M. ; Benke ; D. ; Benson ; J. ; Rudolph ; U.
• 关键词：GABA_A-receptor subtype ; gene transcription ; subcellular targeting
• 刊名：Life Sciences
• 出版年：1998
• 期刊代码：62_00243205
• 类别：imm
• 出版时间：March 27, 1998
• 卷：62
• 期：17-18
• 页码：1611-1615
• 文件大小：278 K

摘要

The rules governing the assembly of GABA_A receptors in vivo were assessed in subunit mutant mice. The transcription of individual subunit genes was regulated independently. The lack of a particular subunit did not result in a molecular rescue by an enhanced transcription of other subunits. In addition, the availability of an α- and β-subunit was essential for receptor formation. Finally, highly selective recognition processes directed the subcellular targeting of receptors. The loss of a particular receptor subtype (α₅) did not lead to a subcellular redistribution of the remaining subtype (α2) present in the same cell.