Copper-catalyzed cyanation of benzyl chlorides with non-toxic K₄[Fe(CN)₆]

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• 作者：Yunlai Ren ; Chuanhua Dong ; Shuang Zhao ; Yanpei Sun ; Jianji Wang ; ^{jwang@mail.haust.edu.cn} ; Junying Ma ; Chaodong Hou
• 关键词：Cyanation ; Benzyl chlorides ; Copper ; Potassium hexacyanoferrate(II)
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：6 June, 2012
• 卷：53
• 期：23
• 页码：2825-2827
• 文件大小：2077 K

摘要

Copper-based catalysts were firstly introduced into the cyanation of benzyl chlorides with non-toxic K₄[Fe(CN)₆]. The presented method avoids the use of extremely poisonous alkali cyanides and precious palladium catalysts. No other reagent apart from CuI, K₄[Fe(CN)₆] and toluene was used in the cyanation, showing that the presented protocol is simple and practical. A series of benzyl chlorides were smoothly cyanated in up to 85%yield under the optimal conditions.