Potential impact of accelerating the primary dose of rotavirus vaccine in infants

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• 作者：Elizabeth E. Halvorson^a ; Timothy R. Peters^a ; Beverly M. Snively^b ; Katherine A. Poehling^a ; ^c ; ^{kpoehlin@wakehealth.edu}
• 关键词：ACIP ; Advisory Committee on Immunization Practices ; CI ; confidence interval ; NNT ; number needed to treat ; U.S. ; United States ; VE ; vaccine efficacy
• 刊名：Vaccine
• 出版年：2012
• 期刊代码：89_0264410x
• 类别：imm
• 出版时间：5 April, 2012
• 卷：30
• 期：17
• 页码：2738-2741
• 文件大小：172 K

摘要

We estimated the potential impact of administering the first dose of rotavirus vaccine at 6 weeks (42 days of life) instead of 2 months of age, which is permissible for all U.S. vaccines recommended at 2 months of age, on rotavirus hospitalization rates. We used published data for hospitalization rates, vaccine coverage, and vaccine efficacy after one dose and assumed a two-week delay in seroconversion after vaccine administration in the United States. Administering the first dose of rotavirus vaccine at 6 weeks instead of 8 weeks of age should have prevented 1110, 1660, and 2210 rotavirus hospitalizations among U.S. infants <3 months of age in 2006 when the vaccine was first introduced. This estimated benefit represents a 2-4%reduction in rotavirus hospitalizations among children <5 years of age.