Anti-TNF therapy induced immune neutropenia in Crohns disease- report of 2 cases and review of literature

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• 作者：Shaji Sebastian ; ^{shaji.Sebastian@hey.nhs.uk} ; Katherine Ashton ; Yasmine Houston ; Tina Mary Diggory ; Philip Dore
• 关键词：Crohn`s ; Neutropenia ; Immune neutropenia ; anti-TNF
• 刊名：Journal of Crohn's and Colitis
• 出版年：2012
• 期刊代码：pca215_18739946
• 类别：med
• 出版时间：July, 2012
• 卷：6
• 期：6
• 页码：713-716
• 文件大小：215 K

摘要

Transient neutropenia is reported in some patients on biologic therapy. We report two cases of severe neutropenia in patients with Crohn`s disease following treatment with anti-TNF therapy. In both cases neutrophil specific granulocyte autoantibodies were detected during period of neutropenia and disappeared on cessation of anti-TNF therapy. These may indicate that anti-TNF agents may produce autoimmune agranulocytosis by triggering production granulocyte autoantibodies. The long term management strategy for patients with anti-TNF therapy induced autoimmune neutropenia is uncertain.