β-Catenin regulates P-cadherin expression in mammary basal epithelial cells
- 作者：Marisa M. Faraldo ; Jé ; rô ; me Teuliè ; re ; Marie-Ange Deugnier ; Walter Birchmeier ; Joerg Huelsken ; Jean Paul Thiery ; Amparo Cano ; Marina A. Glukhova
- 关键词：Basal epithelial cell ; β ; -Catenin ; Mammary gland ; P-cadherin promoter
- 刊名：FEBS Letters
- 出版年：2007
- 期刊代码：70_00145793
- 类别：bio
- 出版时间：6 March 2007
- 卷：581
- 期：5
- 页码：831-836
- 文件大小：937 K
摘要
P-cadherin expression is restricted to the basal layer of stratified epithelia including that of the mammary gland. Although evidence for an important role of P-cadherin in mammary morphogenesis and tumorigenesis is increasing, the mechanisms that regulate its expression are poorly understood. We show that in basal mammary epithelial cells, β-catenin is associated with the P-cadherin promoter and activates its expression independently of LEF/TCF in a cell-type specific manner. Down-regulation of endogenous β-catenin levels by RNA interference technique inhibited P-cadherin promoter activity. In vivo, in skin and mammary gland of mutant mice, activation of β-catenin signalling correlates with up-regulation of P-cadherin expression. These data suggest that β-catenin-dependent modulation of P-cadherin expression can contribute to the establishment of the basal phenotype.