Lack of the PAC₁ receptor alters the circadian expression of VIP mRNA in the suprachiasmatic nucleus of mice

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• 作者：Birgitte Georg ; Jens Hannibal ; Jan Fahrenkrug
• 关键词：Circadian ; PAC1− ; /− ; Real-time RT-PCR ; SCN/suprachiasmatic nucleus ; VIP
• 刊名：Brain Research
• 出版年：2007
• 期刊代码：8_00068993
• 类别：neu
• 出版时间：2 March 2007
• 卷：1135
• 期：1
• 页码：52-57
• 文件大小：237 K

摘要

PACAP in the retinohypothalamic tract mediates photic information to the suprachiasmatic nucleus via the PAC₁ receptor. The diurnal and circadian VIP mRNA expressions in the suprachiasmatic nucleus of PAC₁−/− and wild type mice were quantified. During light/dark cycles identical VIP mRNA rhythms were found while the oscillation pattern differed between the two types of animals during constant darkness. The results show that the circadian VIP mRNA expression is influenced by the absence of PAC₁ signalling.