The determination of carotid intima medial thickness in adults—a population-based twin study
- 作者：Swan ; L. ; Birnie ; D.H. ; Inglis ; G. ; Connell ; J.M.C. ; Hillis ; W.S.
- 关键词：Atherosclerosis ; Genetics ; Intima media thickness twins ; Creat ; plasma creatinine level ; IVS ; inter-ventricular septal thickness (echo) ; LCC ; left common carotid artery ; PW ; posterior wall thickness (echo) ; RCC ; right common carotid artery ; RFW corr ; mean
- 刊名：Atherosclerosis
- 出版年：2003
- 期刊代码：28_00219150
- 类别：med
- 出版时间：January, 2003
- 卷：166
- 期：1
- 页码：137-141
- 文件大小：85.5 K
摘要
Introduction: Although cardiovascular events are known to cluster in families it is unclear the extent to which atherosclerosis per se is genetically determined. The aim of this study was to assess the heritability of carotid intima media thickness (IMT) measurements, a surrogate marker of early atherosclerosis, using a population-based twin study methodology. Methods: B-mode carotid artery ultrasound images were acquired on 264 twin subjects (142 monozygotic (MZ); mean age 54.3 years and 122 dizygotic (DZ); mean age 51.7 years). An estimate of genetic determination, heritability, was calculated for the IMT parameters before and after correction for confounding variables. Results: An increased carotid IMT was associated with known cardiovascular risk factors (total cholesterol r