The cytotoxicity of high-linear energy transfer radiation is reinforced by oxaliplatin in human glioblastoma cells
- 作者：Sami Benzina ; Frederic Debomy ; Jean-Pierre Bergerat ; Jean-Marc Denis ; John Gueulette ; Patrick Dufour ; Pierre Bischoff
- 关键词：Oxaliplatin ; Apoptosis ; Glioblastoma ; Fast neutrons ; High-LET radiation
- 刊名：Cancer Letters
- 出版年：2007
- 期刊代码：44_03043835
- 类别：med
- 出版时间：28 August 2007
- 卷：254
- 期：1
- 页码：54-62
- 文件大小：326 K
摘要
The combination of high-linear energy transfer (LET) radiation with chemotherapeutic agents may offer new perspectives in cancer treatment. We therefore assessed the consequences of a treatment in which U-87 human glioblastoma cells were irradiated with p(65) + Be neutrons in the presence of oxaliplatin, a third generation platinum anticancer drug having higher apoptosis-inducing activity than cisplatin. Cell survival, apoptosis, cell cycle progression as well as p21 and p53 protein expressions were analyzed. Results show that an enhanced cytotoxic effect was obtained when the two treatments were combined and that, unlike what we previously observed with cisplatin, this was not due to a reinforcement of apoptosis. Altogether, our results also indicate the potential of oxaliplatin for use in association with high-LET radiation against tumors refractory to conventional photon radiotherapy.