C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells

详细信息	查看全文 | 推荐本文 |

• 作者：Ko-ichi Kawahara ; Kamal Krishna Biswas ; Masako Unoshima ; Takashi Ito ; Kiyoshi Kikuchi ; Yoko Morimoto ; Masahiro Iwata ; Salunya Tancharoen ; Yoko Oyama ; Kazunori Takenouchi ; Yuko Nawa ; Noboru Arimura ; Me
• 关键词：HMGB1 ; CRP ; Atherosclerosis ; Fcγ ; receptor ; p38MAPK
• 刊名：Cardiovascular Pathology
• 出版年：2008
• 期刊代码：46_10548807
• 类别：med
• 出版时间：May-June 2008
• 卷：17
• 期：3
• 页码：129-138
• 文件大小：572 K

摘要

C-reactive protein (CRP) is widely used as a sensitive biomarker for inflammation. Increasing evidence suggests that CRP plays a role in inflammation. High-mobility group box-1 (HMGB1), a primarily nuclear protein, is passively released into the extracellular milieu by necrotic or damaged cells and is actively secreted by monocytes/macrophages. Extracellular HMGB1 as a potent inflammatory mediator has stimulated immense curiosity in the field of inflammation research. However, the molecular dialogue implicated between CRP and HMGB1 in delayed inflammatory processes remains to be explored.