Intensity-Modulated Radiotherapy Causes Fewer Side Effects than Three-Dimensional Conformal Radiotherapy When Used in Combination With Brachytherapy for the Treatment of Prostate Cancer

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• 作者：Kevin Forsythe ; M.D.^&lowast ; ; Seth Blacksburg ; M.D.^&lowast ; ; Nelson Stone ; M.D.^&dagger ; ; Richard G. Stock ; M.D.^&lowast ; ; ^{richard.stock@moutsinai.org}
• 关键词：Prostate ; Brachytherapy ; Combination ; IMRT ; Toxicity
• 刊名：International Journal of Radiation Oncology*Biology*Physics
• 出版年：2012
• 期刊代码：136_03603016
• 类别：med
• 出版时间：1 June, 2012
• 卷：83
• 期：2
• 页码：630-635
• 文件大小：163 K

摘要

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Purpose

To measure the benefits of intensity-modulated radiotherapy (IMRT) compared with three-dimensional conformal radiotherapy (3D-CRT) when used in combination with brachytherapy for the treatment of prostate cancer.

Methods and Materials

We conducted a retrospective review of all patients with localized prostate cancer who received external-beam radiotherapy (EBRT) in combination with brachytherapy with at least 1 year follow-up (n = 812). Combination therapy consisted of ¹⁰³Pd or ¹²⁵I implant, followed by a course of EBRT. From 1993 to March 2003 521 patients were treated with 3D-CRT, and from April 2003 to March 2009 291 patients were treated with IMRT. Urinary symptoms were prospectively measured with the International Prostate Symptom Score questionnaire with a single quality of life (QOL) question; rectal bleeding was assessed per the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer Late Radiation Morbidity Scoring Schema. The Pearson 蠂² test was used to compare toxicities experienced by patients who were treated with either IMRT or 3D-CRT. Logistic regression analyses were also performed to rule out possible confounding factors.

Results

Within the first 3 months after treatment, patients treated with 3D-CRT scored their urinary symptoms as follows: 19%mild, 44%moderate, and 37%severe; patients treated with IMRT scored their urinary symptoms as follows: 36%mild, 47%moderate, and 17%severe (p聽< 0.001). The 3D-CRT patients rated their QOL as follows: 35%positive, 20%neutral, and 45%negative; IMRT patients rated their QOL as follows: 51%positive, 18%neutral, and 31%negative (p < 0.001). After 1 year of follow-up there was no longer any difference in urinary morbidity between the two groups. Logistic regression confirmed the differences in International Prostate Symptom Score and QOL in the acute setting (p < 0.001 for both). Grade 鈮? rectal bleeding was reported by 11%of 3D-CRT patients and 7%of IMRT patients (p = 0.046); logistic regression analysis also confirmed this observation (p = 0.040).

Conclusions

When used in combination with brachytherapy, IMRT offers less Grade 鈮? rectal bleeding, less acute urinary toxicities, and is associated with a higher QOL compared with 3D-CRT.