Microbleeds relate to altered amyloid-beta metabolism in Alzheimer's disease

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• 作者：Jeroen D.C. Goos^a ; ^b ; ^{j.goos@vumc.nl} ; Charlotte E. Teunissen^a ; ^c ; Robert Veerhuis^a ; ^c ; Nicolaas A. Verwey^a ; ^b ; ^c ; Frederik Barkhof^a ; ^d ; Marinus A. Blankenstein^a ; ^c ; Philip Scheltens^a ; ^b ; Wiesje M. van der Flier^a ; ^b ; ^e ; ^f
• 关键词：Alzheimer's disease ; Vascular dementia ; Cerebral amyloid angiopathy ; MRI ; Cerebrospinal fluid
• 刊名：Neurobiology of Aging
• 出版年：2012
• 期刊代码：202_01974580
• 类别：med
• 出版时间：May, 2012
• 卷：33
• 期：5
• 页码：1011.e1-1011.e9
• 文件大小：926 K

摘要

Cerebral microbleeds (MBs) may relate to amyloid in dementia. We selected 26 probable Alzheimer's disease (AD) patients with MBs, 26 age- and sex-matched AD patients without MBs, 11 vascular dementia (VaD) patients, and 22 patients with subjective complaints. We measured amyloid beta 1-42 (A尾42) and 1-40 (A尾40) in cerebrospinal fluid (CSF) and plasma, and blood-brain barrier (BBB) function using albumin ratios. CSF A尾42 was lowest in AD with MBs, whereas A尾40 was selectively decreased in VaD. In plasma, amyloid-beta was nonsignificantly elevated in VaD compared with controls. Higher albumin ratios in VaD suggested blood-brain barrier dysfunction. A MB pattern suggestive of cerebral amyloid angiopathy (CAA) related to lower CSF A尾42, while a non-cerebral amyloid angiopathy specific MB distribution related to higher plasma A尾40. Amyloid-beta is differentially implicated in AD with MBs and VaD. MB distribution related to different amyloid profiles, supporting distinct etiologies. Our results suggest that A尾42 is retained in cerebrovasculature of AD patients with MBs, while in contrast, VaD patients may possibly drain amyloid.