Reduced cerebrospinal HVA concentrations and HVA/5-HIAA ratios in suicide attempters: Monoamine metabolites in 120 suicide attempters and 47 controls

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• 作者：Engströ ; m ; Gunnar ; Alling ; Christer ; Blennow ; Kaj ; Regné ; ll ; Gö ; ran ; Trä ; skman-Bendz ; Lil
• 关键词：Monoamine metabolites ; Serotonin ; Dopamine ; Suicide ; Depression
• 刊名：European Neuropsychopharmacology
• 出版年：1999
• 期刊代码：95_0924977x
• 类别：med
• 出版时间：September, 1999
• 卷：9
• 期：5
• 页码：399-405
• 文件大小：68.6 K

摘要

Dysfunctions of central monoaminergic systems are important elements of the leading biological hypotheses of suicide and depression. The purpose of the present paper was to study the levels and the relationships between the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), the dopamine metabolite homovanillic acid (HVA) and the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) in the cerebrospinal fluid (CSF) in 120 hospitalised suicide attempters and 47 controls (healthy volunteers or patients admitted for minor surgery). The suicide attempters showed significantly lower HVA levels (174±82 vs. 216±96 nmol/L, P