Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia
- 作者：Diamandis ; Eleftherios P. ; Scorilas ; Andreas ; Kishi ; Tadaaki ; Blennow ; Kaj ; Luo ; Liu-Ying ; et. al.
- 关键词：Human kallikreins ; Serine proteases ; Alzheimer's disease ; Frontotemporal dementia ; NC ; normal controls ; Cerebrospinal fluid ; AD ; Alzheimer's disease ; FTD ; frontotemporal dementia ; APP ; amyloid precursor protein ; MSP ; myelencephalon-specific protease ; A
- 刊名：Clinical Biochemistry
- 出版年：2004
- 期刊代码：55_00099120
- 类别：med
- 出版时间：March, 2004
- 卷：37
- 期：3
- 页码：230-237
- 文件大小：237 K
摘要
Background: The role of various proteases in the pathogenesis of Alzheimer's disease is well documented. Recently, many members of the human tissue kallikrein family, a group of 15 secreted serine proteases, were found to be highly expressed in the central nervous system (CNS). Some of these enzymes can be measured in cerebrospinal fluid (CSF) by using ELISA-type methodologies.