Elevated cerebrospinal fluid F2-isoprostane levels indicating oxidative stress in healthy siblings of multiple sclerosis patients
- 作者：Niklas Mattsson ; Sara Haghighi ; Oluf Andersen ; Yuemang Yao ; Lars Rosengren ; Kaj Blennow ; Domenico Praticò ; ; Henrik Zetterberg
- 关键词：Oxidative stress ; Lipid peroxidation ; Isoprostanes ; Multiple sclerosis
- 刊名：Neuroscience Letters
- 出版年：2007
- 期刊代码：52_03043940
- 类别：neu
- 出版时间：13 March 2007
- 卷：414
- 期：3
- 页码：233-236
- 文件大小：156 K
摘要
Lipid peroxidation has been implicated in the pathogenesis of multiple sclerosis (MS). Isoprostanes, isomers of prostaglandins, are produced by free radical-mediated peroxidation of fatty acids in vivo and can be quantified in biological fluids. This study examines the levels of cerebrospinal fluid (CSF) F2-isoprostanes (F2-iPs) in MS patients (n = 46), their healthy siblings (n = 46) and unrelated controls (n = 50). The median CSF F2-iP concentration (range) was significantly higher in siblings of MS patients, as compared to healthy controls (40.0 [7.1–68.7] and 29.1 [6.4–60.3] pg/mL, respectively, p = 0.031). MS patients demonstrated F2-iP levels intermediate between siblings and controls. F2-iP levels in MS patients and siblings correlated significantly (R = 0.360, p = 0.012). These results suggest that siblings of MS patients have an increased oxidative stress response to environmental and/or genetic factors that may be involved in MS pathogenesis.