Primary B cell repertoire remodeling to achieve humoral transplantation tolerance

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• 作者：Ronald F. Parsons¹ ; Robert R. Redfield III¹ ; Eduardo Rodriguez ; Moiz M. Mustafa ; Kumar Vivek ; Michael Murayama ; Ali Naji ; Hooman Noorchashm ; ^{hooman.noorchashm@uphs.upenn.edu}
• 关键词：B lymphocytes ; Humoral tolerance ; Transplantation ; BLyS
• 刊名：Seminars in Immunology
• 出版年：2012
• 期刊代码：105_10445323
• 类别：imm
• 出版时间：April, 2012
• 卷：24
• 期：2
• 页码：109-114
• 文件大小：686 K

摘要

The current mainstay of immunotherapy in clinical transplantation is T lymphocyte directed. However, it has long been appreciated that the emergence of an alloimmune response mounted by the B lymphocyte compartment and detectable as donor-specific antibodies is a critical challenge to long-term graft survival. Thus, achieving robust transplantation tolerance will require induction of tolerance in both the T- and B-cell compartments. Here we propose that the natural developmental propensity of the B-lymphocyte compartment acquisition of tolerance to self-antigens can be recapitulated to achieve humoral transplantation tolerance. It is our contention B-lymphocyte directed induction immunotherapy would be an important component of emerging strategies for induction of Transplantation tolerance.