BMP4 expression in the developing rat retina

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• 作者：Yuka Maruyama ; Sumiko Mikawa ; Yoshihiro Hotta ; Kohji Sato
• 关键词：BMP4 ; Retina ; Immunohistochemistry ; Retinal ganglion cell ; Inner plexiform layer
• 刊名：Brain Research
• 出版年：2006
• 期刊代码：8_00068993
• 类别：neu
• 出版时间：29 November 2006
• 卷：1122
• 期：1
• 页码：116-121
• 文件大小：900 K

摘要

We investigated the expression of bone morphogenetic protein-4 (BMP4) in the developing retina. At E19, we found very intense BMP4 immunoreactivity (IR) in the nerve fiber layer. At P1, the inner plexiform layer exhibited very strong BMP4-IR. Thereafter, abundant BMP4 expression was kept to the adult period. These results suggest that BMP4 plays pivotal roles in the retina not only in the early embryonic period but also in the late embryonic and postnatal periods, and even in the adult.