Cytomegalovirus uses multiple strategies to interfere with MHC class I-restricted antigen presentation

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• 作者：Wiertz ; Emmanuel J.H.J. ; Tortorella ; Domenico ; Bogyo ; Matt ; Yu ; Joyce ; Galocha ; Begona ; Mothes ; Walther ; et. al.
• 刊名：Immunology Letters
• 出版年：1997
• 期刊代码：115_01652478
• 类别：med
• 出版时间：May, 1997
• 卷：56
• 期：1-3
• 页码：189
• 文件大小：139 K

摘要

Introduction: In cells infected with human cytomegalovirus (HCMV) down-regulation of MHC class I expression is observed. In the absence of functional MHC class I complexes, the infected cells will escape from destruction by cytotoxic T cells. Surprisingly, HCMV achieves this goal by multiple strategies involving different gene products. Four of these gene products, US2, US3, US6 and US11, were identified using recombinant HCMV's with overlapping deletions in the unique short (US) region.