Radiolabelling, quality control and radiochemical purity assessment of the Octreotide analogue ⁶⁸Ga DOTA NOC

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• 作者：D. Di Pierro ; A. Rizzello ; G. Cicoria ; F. Lodi ; M. Marengo ; D. Pancaldi ; S. Trespidi ; S. Boschi
• 关键词：PET radiopharmaceuticals ; ⁶⁸Ga-labelled DOTA NOC ; NET ; Somatostatin receptors ; Radiochemical stability ; Quality control
• 刊名：Applied Radiation and Isotopes
• 出版年：2008
• 期刊代码：6_09698043
• 类别：ce
• 出版时间：August 2008
• 卷：66
• 期：8
• 页码：1091-1096
• 文件大小：512 K

摘要

Somatostatin receptors 1–5 are over expressed in neuroendocrine tumours (NETs). ⁶⁸Ga-labelled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-Nal3-Octreotide (DOTA NOC), a recent synthesized somatostatin analogue, shows high affinity for those receptors. Herein, modifications of a commercial module for the labelling of DOTA NOC with ⁶⁸Ga, as well as the assessment of time course of the radiochemical purity variation are described. The evaluation of radiochemical stability was done by two different chromatographic methods: reversed-phase radio HPLC and fast TLC analysis. Labelled compound has been found radiochemically stable within 3 h from the end of labelling (EOL) and radiochemical purity was always higher than 99%. After 73 labelling sessions the system showed great reproducibility and high radiochemical yield.