Stable coreceptor usage of HIV in patients with ongoing treatment failure on HAART

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• 作者：Clara Lehmann ; Martin Dä ; umer ; Ibrahim Boussaad ; Tobias Sing ; Niko Beerenwinkel ; Thomas Lengauer ; Norbert Schmeisser ; Christoph Wyen ; Gerd Fä ; tkenheuer ; Rolf Kaiser
• 关键词：HIV ; Chemokine receptors ; Virus tropism ; HAART failure ; Resistance
• 刊名：Journal of Clinical Virology
• 出版年：2006
• 期刊代码：150_13866532
• 类别：med
• 出版时间：December 2006
• 卷：37
• 期：4
• 页码：300-304
• 文件大小：122 K

摘要

>Background

Disease progression in HIV infection has been associated with switch of viral coreceptor usage from CCR5 to CXCR4.

Objectives

To investigate the relationship between HIV-coreceptor tropism and clinical and virological outcome in 40 heavily pretreated patients over time.

Methods

Coreceptor phenotype was predicted after sequencing the V3 loop of the HIV glycoprotein 120.

Results

Coreceptor use was stable during observation time in 87%of patients, and CCR5 tropism was predominant. Viral mutations in the pol gene and clinical parameters were not predictive for coreceptor switching.

Conclusions

Even in patients with repeated HAART failure, CCR5 antagonists might be a valuable treatment option.