Fetal protection against bovine viral diarrhoea type 1 virus infection after one administration of a live-attenuated vaccine

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• 作者：Gilles Meyer^a ; ^b ; ^{g.meyer@envt.fr} ; Martine Deplanche^a ; Dominique Roux^b ; Martine Moulignie^a ; Nicole Picard-Hagen^c ; ^d ; Faouzi Lyazrhi^d ; Didier Raboisson^b ; Pierre Mathevet^e ; Franç ; ois Schelcher^a ; ^b
• 关键词：Bovine viral diarrhoea virus ; Vaccination ; Cattle ; Fetus ; Persistent infection
• 刊名：The Veterinary Journal
• 出版年：2012
• 期刊代码：338_10900233
• 类别：med
• 出版时间：May, 2012
• 卷：192
• 期：2
• 页码：242-245
• 文件大小：349 K

摘要

A modified-live vaccine has been shown previously to prevent fetal infection with bovine viral diarrhoea virus (BVDV)-2 and, to some extent BVDV-1, when used in association with an inactivated vaccine in a two-step vaccination protocol. In this challenge study, the modified-live vaccine used alone was able to protect 13 heifers between 49 and 96 days of gestation at challenge from leucopenia and virus replication and, for a 4-month period, to prevent fetal infection. The efficacy of the BVDV-1f 22146/Han81 challenge was demonstrated by virus isolation from the fetuses of all nine non-vaccinated, control heifers. However, the small number of heifers tested meant that the vaccination failure rate could be as high as 10%in the field.