The immune modulation of Bacillus cereus var. Toyoi in mice immunized with experimental inactivated Bovine Herpesvirus Type 5 vaccine

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• 作者：Talita Bandeira Roos^a ; Ana Paula de Souza Stori de Lara^b ; Luana Alves Dummer^c ; Geferson Fischer^a ; Fá ; bio Pereira Leivas Leite^c ; ^{fabio_leite@ufpel.edu.br} ; ^{fabio@leivasleite.com.br}
• 关键词：APCs ; antigen presenting cells ; CFU ; colony forming units ; MDCK cells ; Madin Darby canine kidney cells ; TCID50 ; tissue culture dose infection 50
• 刊名：Vaccine
• 出版年：2012
• 期刊代码：89_0264410x
• 类别：imm
• 出版时间：9 March, 2012
• 卷：30
• 期：12
• 页码：2173-2177
• 文件大小：335 K

摘要

In recent years, there been significant progress toward develop more efficient vaccines. Different compounds with adjuvant capacity have been tested; however, no compound has emerged that suitable for universal use. Several efforts have been made to produce effective vaccines against Bovine herpesvirus 5 (BoHV-5), an important cattle pathogen. In this study we examine the use the probiotic Bacillus cereus var. Toyoi as a potential adjuvant to improve BoHV-5 vaccine efficacy. We observed in the supplemented animals a systemic enhanced IgG antibody response toward Th1, and increased IFN-纬, IL-12 and IL-10 cytokines mRNA levels. These results suggest that this probiotic could provide a promising means of improving vaccine efficacy, particularly those vaccines that rely on a cell-mediated immune response.