We studied 538 Japanese type 2 diabetic patients, 227 women and 311 men, with a mean [卤SD] age of 64 卤 11 years. All patients underwent cranial magnetic resonance imaging (MRI). Values of ABI were classified as low (<0.9), normal (0.9鈮?and <1.3), and high (1.3鈮?. Logistic regression model was used to calculate odds ratio and 95%confidence interval (95%CI) for prevalent SCI.
The mean ABI among the overall 538 patients was 1.09 卤 0.16. Low and high ABI values were found in 52 (9.7%) and 33 (6.1%) patients, respectively. SCI was detected in 297 (55.2%) patients. The prevalence in patients with low, normal, and high ABI values were 88.5%, 49.7%, and 78.8 (p < 0.001), respectively. In the multivariate logistic regression analysis, both patients with high and low ABI were significantly increased risk of prevalent SCI (odds ratio 4.53, 95%CI 1.67-12.34, p = 0.003 and odds ratio 3.50, 95%CI 1.50-10.29, p = 0.005), independently of other traditional cardiovascular risk factors, than those with normal ABI.
Both high and low ABI may be strongly associated with prevalent SCI in Japanese patients with type 2 diabetes.