Between 20th July 1998 and 7th February 2006, 1500 patients underwent I-125 prostate brachytherapy without supplemental external beam radiation therapy. Of these, 439 had Gleason 7 disease; 362 had Gleason 3 + 4 and 77 had 4 + 3 disease. Generally, patients received 6 months of androgen suppression. We compared biochemical no evidence of disease (bNED) between patients with Gleason 猢? and Gleason 7 and between Gleason 3 + 4 and 4 + 3 using the Phoenix definition of biochemical recurrence.
Median follow-up was 60 months. Estimated 5 year bNED was 97%for patients with Gleason score 猢? and 94%for patients with Gleason 7 disease (p = 0.037). Estimated bNED was 95%and 94%for 3 + 4 and 4 + 3, respectively (p = 0.791). There was no difference in bNED between implants achieving D90 猢?#xA0;versus < the median value (150.5 Gy) or 猢?#xA0;versus < 140 Gy.
I-125 brachytherapy with 6 months of ADT demonstrates excellent bNED rates in Gleason 7 disease. We found no evidence of a difference between patients with Gleason 3 + 4 versus 4 + 3 disease.