Hepatitis B virus genotypes from European origin explains the high endemicity found in some areas from southern Brazil

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• 作者：Dennis Armando Bertolini^a ; ^{dabertolini@uem.br} ; Michele Soares Gomes-Gouvê ; a^b ; Isabel Maria Vicente Guedes de Carvalho-Mello^c ; Clá ; udia Patara Saraceni^d ; Roberta Sitnik^e ; Felipe Gobbi Grazziotin^f ; Jomar Pereira Laurindo^h ; Nelson Jurandi Rosa Fagundes^f ; ^g ; Flair José ; Carrilho^b ; Jo&atilde ; o Renato Rebello Pinho^b ; ^e
• 关键词：Hepatitis B virus ; Genotypes ; Genotype D ; Migration ; Brazil ; Europe
• 刊名：Infection ; Genetics and Evolution
• 出版年：2012
• 期刊代码：119_15671348
• 类别：med
• 出版时间：August, 2012
• 卷：12
• 期：6
• 页码：1295-1304
• 文件大小：1954 K

摘要

Southern Brazil is considered an area of low Hepatitis B endemicity, but some areas of higher endemicity have been described in the Southwest of Paran谩 and Santa Catarina states. The aim of this study was to evaluate viral genotypes circulating throughout Paran谩 state. PCR amplification and partial sequencing of the S gene was carried out in 228 samples from HBsAg positive candidate blood donors. Samples have been collected in seven different counties (Cascavel, Curitiba, Foz do Igua莽u, Francisco Beltr茫o, Maring谩, Londrina and Paranagu谩). The most common HBV genotype in Paran谩 state was D (82.9%; 189/228), followed by A (14.1%; 32/228). Genotypes F (1.3%; 3/228), C (1.3%; 3/228) and H (0.4%; 1/228) were also found. Distribution of genotypes was different in the studied counties, but genotype D was the most frequent in all of them. In Francisco Beltr茫o, all studied samples belonged to genotype D. The high prevalence of HBV genotype D in South of Brazil is explained by the intense migration of settlers from Europeans countries. Subgenotypes A1 and A2 were identified circulating in all cities where HBV/A was found. As observed in other areas of Brazil, HBV/A1 is more frequent than the HBV/A2 in Paran谩 state and its presence was significantly larger in black and mulatto individuals. Genotype C was found only in individuals with Asian ancestry from Londrina and Maring谩. Most HBV/F sequences identified in this study were classified as subgenotype F2a that was previously described in Brazil. The sole case of subgenotype F4 was from Foz do Igua莽u city, near to Northern Argentina, where F4 is highly prevalent. The single genotype H sample was from Curitiba. This is the first case of this genotype described in Brazil. Further studies should be carried out to determine if more genotype H samples can be found in other populations from Brazil.