Prediction of cognitive decline after stroke using proton magnetic resonance spectroscopy

详细信息	查看全文 | 推荐本文 |

• 作者：Amy J. Ross ; Perminder S. Sachdev ; Wei Wen ; Henry Brodaty ; Amy Joscelyne ; Lisa M. Lorentz
• 关键词：Stroke ; TIA ; Vascular cognitive impairment ; Proton magnetic resonance spectroscopy ; MRI ; Ageing
• 刊名：Journal of the Neurological Sciences
• 出版年：2006
• 期刊代码：178_0022510x
• 类别：med
• 出版时间：21 December 2006
• 卷：251
• 期：1-2
• 页码：62-69
• 文件大小：381 K

摘要

Structural MRI measures have been used to predict cognitive decline in elderly subjects, but few studies have used proton magnetic resonance spectroscopy (¹H-MRS) for this purpose, particularly after stroke. We studied the potential of ¹H-MRS to predict cognitive decline in patients with stroke or TIA and healthy ageing controls over 12 months and 3 years. Structural MRI and single-voxel ¹H-MRS in the frontal white matter and the occipito-parietal gray matter were performed at the index assessment (3–6 months post-stroke) in 49 stroke/TIA patients and 60 controls. Neuropsychological testing was performed at the index assessment and repeated at 12 months in 30 stroke/TIA patients and 49 controls, and at 3 years in 25 patients and 48 controls. In stroke/TIA patients, frontal NAA/Cr predicted cognitive decline over 12 months and 3 years, and in elderly control subjects frontal NAA predicted cognitive decline over 12 months only. In stroke/TIA patients, the ¹H-MRS measures were better predictors of cognitive decline than structural measures. ¹H-MRS may be useful in assessing early cognitive impairment after stroke/TIA and in normal ageing.