Depressive Psychomotor Disturbance, Cortisol, and Dexamethasone
- 作者：Mitchell ; Philip ; Hadzi-Pavlovic ; Dusan ; Parker ; Gordon ; Hickie ; Ian ; Wilhelm ; Kay ; Brodaty ; Henry ; et. al.
- 关键词：Melancholia ; psychomotor disturbance ; dexamethasone ; cortisol ; depression ; classification
- 刊名：Biological Psychiatry
- 出版年：1996
- 期刊代码：34_00063223
- 类别：med
- 出版时间：November 15, 1996
- 卷：40
- 期：10
- 页码：941-950
- 文件大小：891 K
摘要
We examine the dexamethasone suppression test as a biological correlate of melancholia as defined by the CORE system, a scale for rating objective signs of psychomotor disturbance. Postdexamethasone cortisol concentrations and rates of nonsuppression were higher in CORE, Newcastle, and DSM-III-R defined melancholic groups. These differences, however, were no longer significant after partialling out the combined effects of age, dexamethasone, and basal cortisol concentrations. There was a significant correlation between the CORE (but not the Newcastle) scale and 8:00 am postdexamethasone cortisol levels, which persisted after partialling out those same three covariates. Dexamethasone concentrations themselves were lower in CORE- and Newcastle-defined melancholics, though these were no longer significant after covarying for cortisol concentrations. Dexamethasone levels were also significantly inversely correlated with CORE and Newcastle scales. A significant correlation between CORE (but not Newcastle) scores and dexamethasone levels at 4:00 pm persisted after partialling out the effects of age and cortisol. These findings indicate an intriguing relationship between the CORE system as a dimensional construct for rating psychomotor disturbance, and both postdexamethasone cortisol and dexamethasone concentrations.