Reproducibility of and Effect of Magnification on Optical Coherence Tomography Measurements in Children

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• 作者：Xiu Ying Wang ; Son C. Huynh ; George Burlutsky ; Jenny Ip ; Fiona Stapleton ; Paul Mitchell
• 刊名：American Journal of Ophthalmology
• 出版年：2007
• 期刊代码：7_00029394
• 类别：med
• 出版时间：March 2007
• 卷：143
• 期：3
• 页码：484-488.e2
• 文件大小：656 K

摘要

Purpose

To determine the reproducibility of optical coherence tomography (OCT) measurements of macular thickness, peripapillary nerve fiber layer (NFL) thickness, and optic disk parameters and to investigate the effect of axial length and refractive error on these measurements in children with healthy eyes.

Design

Cross-sectional study.

Methods

The Sydney Childhood Eye Study examined 2,353 year 7 students (75.3%response) from a random cluster sample of 21 secondary schools across Sydney. A consecutive subsample of 120 children had OCT (StratusOCT, Carl Zeiss, Dublin, California, USA) performed by a single operator, which was repeated with a brief rest between the two sessions. Scans of the NFL, macula, and optic disk were performed.

Results

Intersubject variability of measurements of macular thickness, NFL thickness, and optic disk parameters assessed using intraclass correlation coefficients accounted for >85%, >62%, and >38%of total variability of measurements, respectively. Corresponding coefficients of variability were <5%, <8%, and <13%. Magnification effects attributable to axial length and refractive error on the measurement of these parameters were statistically not significant.

Conclusion

The StratusOCT demonstrated reproducible measurements of macular and NFL thickness. Measurement of most optic disk parameters were also reproducible. Magnification attributable to axial length and refractive error had minimal impact on measurements of macular and NFL thickness.