Effects of exogenous carbon monoxide on radiation-induced bystander effect in zebrafish embryos in vivo

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• 作者：V.W.Y. Choi^a ; M.Y.P. Wong^a ; S.H. Cheng^b ; ^c ; K.N. Yu^a ; ^c ; ^{appetery@cityu.edu.hk}
• 关键词：Alpha particles ; Bystander effect ; Zebrafish embryos ; CO ; CORM-3
• 刊名：Applied Radiation and Isotopes
• 出版年：2012
• 期刊代码：6_09698043
• 类别：ce
• 出版时间：July, 2012
• 卷：70
• 期：7
• 页码：1075-1079
• 文件大小：302 K

摘要

In the present work, the influence of a low concentration of exogenous carbon monoxide (CO) liberated from tricarbonylchloro(glycinato)ruthenium (II) (CORM-3) on the radiation induced bystander effect (RIBE) in vivo between embryos of the zebrafish was studied. RIBE was assessed through the number of apoptotic signals revealed on embryos at 25 h post fertilization (hpf). A significant attenuation of apoptosis on the bystander embryos induced by RIBE in a CO concentration dependent manner was observed.