β-Hydroxy-β-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factor-
- 作者：Everson Araú ; jo Nunes ; Diogo Kuczera ; Gleisson Alisson Pereira Brito ; S ; ro J.R. Bonatto ; Ricardo Key Yamazaki ; Ricardo Antonio Tanhoffer ; Rogé ; ria Campus Mund ; Marcelo Kryczyk ; Luiz Claudio Fe
- 关键词：Cancer cachexia ; β ; -Hydroxy-β ; -methylbutyrate (HMB) supplementation ; Tumor growth ; Cell proliferation ; Walker 256 rat
- 刊名：Nutrition Research
- 出版年：2008
- 期刊代码：123_02715317
- 类别：bio
- 出版时间：July 2008
- 卷：28
- 期：7
- 页码：487-493
- 文件大小：198 K
摘要
Cancer cachexia syndrome contributes to wasting and weight loss leading to inefficacy of anticancer therapy. In this study, the anticatabolic agent β-hydroxy-β-methylbutyrate (HMB) was supplemented to adult Walker 256 tumor-bearing rats during 8 weeks aiming to determine if tumor burden could be reduced. Male Wistar rats were randomly assigned to nontumor and tumor-bearing groups and fed regular chow or regular chow plus HMB supplemented (76 mg/kg body weight). β-Hydroxy-β-methylbutyrate supplementation induced a lower tumor weight and tumor cell proliferation ex vivo, totally prevented glycemia reduction, as well as blunted the increase in the serum lactate concentrations and also preserved glycogen stores in tumor-bearing rats. Reduction in tumor cell proliferation ex vivo was accompanied by increased nuclear factor-κB inhibitor-
content by more than 100%. In contrast, nuclear factor-κB p65 subunit content was suppressed by 17%with HMB supplementation. In conclusion, HMB supplementation, at a similar dose used in humans to increase muscle mass, caused antitumor and anticachectic effects, with tumor-cell nuclear factor-κB pathway participation, which might be a potential nutritional strategy in cancer therapy.
content by more than 100%. In contrast, nuclear factor-κB p65 subunit content was suppressed by 17%with HMB supplementation. In conclusion, HMB supplementation, at a similar dose used in humans to increase muscle mass, caused antitumor and anticachectic effects, with tumor-cell nuclear factor-κB pathway participation, which might be a potential nutritional strategy in cancer therapy.