The influence of rapid-rate transcranial magnetic stimulation was examined on heart rate and blood pressure in 13 healthy volunteers. 5 stimuli of each location were applied with a Cadwell high speed magnetic stimulator using a focal pointed circular coil. Stimulus frequency was 20 Hz. ECG and blood pressure (Finapres) were recorded continuously during the one-hour test. Throughout the experiments no clinically relevant side-effects were observed. In all subjects there was a clearly marked autonomic response with heart rate acceleration and decrease in blood pressure after all stimuli. However, there was no difference in responses between different cortical stimulus localisations.