Uso de los f谩rmacos antagonistas del factor de necrosis tumoral en las enfermedades autoinmunes: situaci贸n actual

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• 作者：Daniel Sá ; nchez Cano ; ^{danifilax@gmail.com} ; José ; Luis Callejas Rubio ; Norberto Ortego Centeno
• 关键词：Anti-TNF ; Autoimmune diseases ; Inflammatory diseases
• 刊名：Medicina Cl铆nica
• 出版年：2008
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：October 2008
• 卷：131
• 期：12
• 页码：471-477
• 文件大小：88 K

摘要

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Summary

Tumor necrosis factor (TNF) alpha plays a central role in both the inflammatory response and that of the immune system. Thus, its blockade with the so-called anti-TNF agents (infliximab, etanercept and adalimumab) represnts an important tool for the management of a variety of disorders, such as rheumatoid arthritis, the spondyloarthropaties, inflammatory bowel disease and psoriasis. Nonetheless, theoretically, some other autoimmune and inflammatory disorders may benefit from these agents. We intend to update on these off-label uses of anti-TNF blockers in this review.