Ionic liquid-aqueous solution ultrasonic-assisted extraction of camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata samara

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• 作者：Chun-hui Ma^a ; ^b ; ¹ ; Shu-ya Wang^a ; ^b ; ¹ ; Lei Yang^a ; ^b ; ^{ylmanefu@163.com} ; Yuan-gang Zu^a ; ^b ; ^{zygorl@126.com} ; Feng-jian Yang^a ; ^b ; Chun-jian Zhao^a ; ^b ; Lin Zhang^a ; ^b ; Zhong-hua Zhang^a ; ^b
• 关键词：Camptotheca acuminata ; Camptothecin ; 10-Hydroxycamptothecin ; Ionic liquid ; Ultrasonic-assisted extraction ; Response Surface Methodology
• 刊名：Chemical Engineering and Processing
• 出版年：2012
• 期刊代码：15_02552701
• 类别：ce
• 出版时间：July-August, 2012
• 卷：57-58
• 期：Complete
• 页码：59-64
• 文件大小：804 K

摘要

In this paper, ionic liquid-aqueous solution ultrasonic-assisted extraction (ILUAE) has been successfully applied in extracting camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata samara. The ionic liquids with different cations and anions have been investigated, and 0.75 M 1-octyl-3-methylimidazolium bromide was selected as solvent. In addition, the ultrasonic parameters including ultrasonic power, time for ultrasonic treatment and solid-liquid ratio have been optimized by Response Surface Methodology. Compared with conventional solvent extraction, ILUAE exhibited higher efficiency (camptothecin increased by 13.96%and 10-hydroxycamptothecin increased by 24.04%, respectively) and shorter extraction time (decreased from 6 h to 1.75 h for extracting three times), which indicated that ILUAE was an efficient, rapid and simple sample preparation technique.