The purposes of this study were to determine the occurrence rate for preoperative breast
pain; describe the characteristics of this
pain; evaluate for differences in demographic and clinical characteristics; and evaluate for variations in pro- and anti-inflammatory cytokine genes between women who did and did not report
pain. Patients (n = 398) were recruited prior to surgery and completed self-report questionnaires on a number of
pain characteristics. Genotyping was done using a custom genotyping array. Women (28.2%) who reported breast
pain were significantly younger (
P < .001); more likely to be nonwhite (
P = .032); reported significantly lower Karnofsky Performance Status scores (
P = .008); were less likely to be postmenopausal (
P = .012); and had undergone significantly more biopsies (
P = .006). Carriers of the minor allele for a single nucleotide polymorphism in interleukin (IL)1-receptor 1 (IL1R1) (rs2110726) were less likely to report breast
pain prior to surgery (
P = .007). Carriers of the minor allele for a single nucleotide polymorphism in IL13 (rs1295686) were more likely to report breast
pain prior to surgery (
P = .019). Findings suggest that breast
pain occurs in over a quarter of women who are about to undergo breast
cancer surgery. Based on phenotypic and genotypic characteristics found, inflammatory mechanisms contribute to preoperative breast
pain.
Perspective
In women with breast cancer, preoperative pain may be associated with increases in inflammatory responses associated with an increased number of biopsies. In addition, differences in cytokine genes may contribute to this preoperative breast pain.