A phase II trial for the optimisation of treatment position in the radiation therapy of prostate cancer
- 作者：Louise O’ ; Neill ; John Armstrong ; Steve Buckney ; Mushabbab Assiri ; Mairin Cannon ; Ola Holmberg
- 关键词：Treatment position ; Prostate cancer ; Radiation therapy ; Rectum ; Bladder
- 刊名：Radiotherapy and Oncology
- 出版年：2008
- 期刊代码：231_01678140
- 类别：med
- 出版时间：July 2008
- 卷：88
- 期：1
- 页码：61-66
- 文件大小：227 K
摘要
Patient immobilisation and position are important contributors to the reproducibility and accuracy of radiation therapy. In addition the choice of position can alter the external contour of the treated area and has the potential to alter the spatial relationship between internal organs. The published literature demonstrates variation in the use of the prone and supine position for prostate cancer radiation therapy. Previous investigators using different protocols for patient preparation, imaging and target volume definition have demonstrated changes in the calculated therapeutic ratio comparing the two positions. We did not use rigid immobilisation, laxatives, rectal catheters or bladder voiding and assessed if in the prone position would cause a reduction of the dose to the rectum. We performed a prospective comparison of the two positions in 26 patients to determine if the differences in the spatial relation between the rectum and the planning target volume (PTV) would impact on dose–volume histograms to organs at risk (OAR). We also determined if any such improvement might permit dose escalation.