Hydroxyapatite-armored poly(蔚-caprolactone) microspheres and hydroxyapatite microcapsules fabricated via a Pickering emulsion route

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• 作者：Syuji Fujii^a ; ^{s.fujii@chem.oit.ac.jp} ; Masahiro Okada^b ; ^{okada-m@cc.osaka-dent.ac.jp} ; Taiki Nishimura^a ; Hayata Maeda^a ; Tatsuya Sugimoto^a ; Hiroyuki Hamasaki^a ; Tsutomu Furuzono^c ; Yoshinobu Nakamura^a ; ^d
• 关键词：Hydroxyapatite ; Pickering emulsion ; Poly(蔚-caprolactone) ; Microsphere ; Hybrid
• 刊名：Journal of Colloid and Interface Science
• 出版年：2012
• 期刊代码：125_00219797
• 类别：ch
• 出版时间：15 May, 2012
• 卷：374
• 期：1
• 页码：1-8
• 文件大小：1243 K

摘要

Hydroxyapatite (HAp) nanoparticle-armored poly(蔚-caprolactone) (PCL) microspheres were fabricated via a 鈥淧ickering-type鈥?emulsion solvent evaporation method in the absence of any molecular surfactants. It was clarified that the interaction between carbonyl/carboxylic acid groups of PCL and the HAp nanoparticles at an oil-water interface played a crucial role in the preparation of the stable Pickering-type emulsions and the HAp nanoparticle-armored microspheres. The HAp nanoparticle-armored PCL microspheres were characterized in terms of size, size distribution, morphology, and chemical compositions using scanning electron microscopy, laser diffraction, energy dispersive X-ray microanalysis, and thermogravimetric analysis. The presence of HAp nanoparticles at the surface of the microspheres was confirmed by scanning electron microscopy and energy dispersive X-ray microanalysis. Pyrolysis of the PCL cores led to the formation of the corresponding HAp hollow microcapsules.