Cryogenic grinding of electrospun poly-蔚-caprolactone mesh submerged in liquid media

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• 作者：Petr Knotek^a ; ¹ ; ² ; Miloslav Pouzar^b ; ^{milan.pouzar@upce.cz} ; Matej Buzgo^c ; ^d ; Barbora Krizkova^e ; Milan Vlcek^f ; ¹ ; ² ; Andrea Mickova^c ; ^d ; Martin Plencner^c ; ^d ; Jakub Navesnik^b ; Evzen Amler^c ; ^d ; Petr Belina^g
• 关键词：Cryogenic grinding ; Poly-蔚-caprolactone ; Nano/micro-mesh ; Microsystem ; Characterization
• 刊名：Materials Science and Engineering ; C
• 出版年：2012
• 期刊代码：63_09284931
• 类别：ms
• 出版时间：1 August, 2012
• 卷：32
• 期：6
• 页码：1366-1374
• 文件大小：1508 K

摘要

In this paper, the treatment of poly-蔚-caprolactone (PCL) nano/micro-mesh system by cryogenic grinding and subsequent characterization of obtained product is described. The PCL nano/micro-mesh layer submerged in appropriate liquid was cryogenically ground and obtained particles were characterized employing mainly laser diffraction and scanning electron microscopy (SEM). In the ground sample, different types of particles (fibrous particles, fibrous fragments, agglomerates with and without an internal fibrous structure, lamellae and nanoparticles) were identified, described and quantified. Parameters of cryogenic grinding (weight of sample, type of liquid medium, and influence of sample storage) were optimized to maximize the yield of particles with desired features. The potential of the system for cell scaffolding was demonstrated by cultivation of 3T3 fibroblasts on the produced microparticles.