Baseline mean and heterogeneity of MR cartilage T₂ are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3 years - data from the Osteoarthritis Initiative

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• 作者：G.B. Joseph^&dagger ; ; ^{gabby.joseph@ucsf.edu} ; T. Baum^&dagger ; ; ^{thomas-baum@gmx.de} ; H. Alizai^&dagger ; ; ^&Dagger ; ; ^{Alizai@uthscsa.edu} ; J. Carballido-Gamio^&dagger ; ; ^{Julio.Carballido-Gamio@ucsf.edu} ; L. Nardo^&dagger ; ; ^{Lorenzo.Nardo@ucsf.edu} ; W. Virayavanich^&dagger ; ; ^{Warapat.Virayavanich@ucsf.edu} ; J.A. Lynch^§ ; ; ^{JLynch@psg.ucsf.edu} ; M.C. Nevitt^§ ; ; ^{MNevitt@psg.ucsf.edu} ; C.E. McCulloch^§ ; ; ^{CMcCulloch@epi.ucsf.edu} ; S. Majumdar^&dagger ; ; ^{sharmila.majumdar@ucsf.edu} ; T.M. Link^&dagger ; ; ^{Thomas.Link@ucsf.edu}
• 关键词：Osteoarthritis ; Cartilage ; T2 mapping ; Magnetic Resonance Imaging ; Osteoarthritis Initiative
• 刊名：Osteoarthritis and Cartilage
• 出版年：2012
• 期刊代码：249_10634584
• 类别：med
• 出版时间：July, 2012
• 卷：20
• 期：7
• 页码：727-735
• 文件大小：549 K

摘要

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Summary

Objective

The purpose of this study is to determine whether the mean and heterogeneity of magnetic resonance (MR) knee cartilage T₂ relaxation time measurements at baseline are associated with morphologic degeneration of cartilage, meniscus, and bone marrow tissues over 3 years in subjects with risk factors for osteoarthritis (OA).

Design

Subjects with risk factors for OA (n = 289) with an age range of 45-55 years were selected from the Osteoarthritis Initiative (OAI) database. 3.0 Tesla MR images were analyzed using morphological gradings of cartilage, bone marrow and menisci whole-organ magnetic resonance imaging scores (WORMS scoring). A T₂ mapping sequence was used to assess the mean and heterogeneity of cartilage T₂ (gray level co-occurrence matrix texture analysis). Regression models were used to assess the relationship between baseline T₂ parameters and changes in morphologic knee WORMS scores over 3 years.

Results

The prevalence of knee abnormalities in the cartilage (P < 0.0005), meniscus (P < 0.00001), and bone marrow significantly (P < 0.00001) increased from baseline to 3 years in all compartments combined. The baseline mean and heterogeneity of cartilage T₂ were significantly (P < 0.05) associated with morphologic joint degeneration in the cartilage, meniscus and bone marrow over 3 years.

Conclusions

The prevalence of knee abnormalities significantly increased over 3 years; increased cartilage T₂ at baseline predicted longitudinal morphologic degeneration in the cartilage, meniscus, and bone marrow over 3 years in subjects with risk factors for OA.