• 作者：Karina Portillo Carroz^a ; ^{karisoe@yahoo.es} ; Juan Roldá ; n Sá ; nchez^b ; Josep Morera Prat^a
• 关键词：Enfisema ; Fibrosis pulmonar ; Difusió ; n del monó ; xido de carbono ; Hipertensió ; n pulmonar ; Tabaquismo
• 刊名：Archivos de Bronconeumolog铆a
• 出版年：2010
• 期刊代码：pca65_03002896
• 类别：med
• 出版时间：December 2010
• 卷：46
• 期：12
• 页码：646-651
• 文件大小：666 K

The combination of pulmonary fibrosis and emphysema (CPFE) is a recently defined syndrome, in which anupper lobe emphysema and lower lobe fibrosis coexist in a single patient. These patients have a characteristic lung function profile, with dynamic and static lung volumes apparently normal or minimally altered, contrasting with a significant reduction of carbon monoxide transfer (DLco) and exercise hypoxemia. Pulmonary hypertension is highly prevalent and is the principal negative prognostic factor for this condition. High resolution computed axial tomography (HRCT) is the main tool to confirm the diagnosis. Cigarette smoking has been proposed as the main factor in its etiology; however, neither pathogenic mechanisms nor the sequence of events involved in this syndrome has been clarified yet. Experimental studies in animal models are providing information on the involvement of some inflammatory mediators in the pathogenesis. There is currently no consensus on the therapeutic approach to be followed in these patients, since those published to date on this subject are limited to well-characterised series of cases. Therefore, it is a pathology with many unknowns yet to be resolved and highly likely to be underdiagnosed, unless its functional clinical characteristics are taken into acount.