Carcinine-β-cyclodextrin derivatives as scavenger entities of OH radicals and SOD-like properties of their copper(II) complexes
- 作者：Raffaele Pietro Bonomo ; Franca D’ ; Aless ; ro ; Giulia Grasso ; Giuseppe Impellizzeri ; Giuseppe Pappalardo ; Enrico Rizzarelli ; Giovanni Tabbì
- 关键词：Copper ; Cyclodextrin derivative ; Carcinine ; Superoxide radical ; Hydroxyl radical
- 刊名：Inorganica Chimica Acta
- 出版年：2008
- 期刊代码：40_00201693
- 类别：ch
- 出版时间：5 May 2008
- 卷：361
- 期：6
- 页码：1705-1714
- 文件大小：271 K
摘要
6-Deoxy-6-{4-[N-(2-aminoethyl)propaneamide]imidazolyl}cyclohepta amylose (CDcarc) and 6-{3-amine-N-[2-(imidazol-4-yl)ethyl]propaneamide}-6-deoxycyclohepta amylose (CDcrac) were synthesized with the aim to obtain copper(II) complexes able to scavenge superoxide radical. The copper(II) complexes were studied by means of UV–Vis, ESR, CD, ESI-MS spectroscopies to gain information about the species present in solution as function of the pH. The antioxidant activity was assayed against superoxide enzymatically generated and compared with that obtained from copper(II) complex with underivatized carcinine. The hydroxyl radical scavenging ability of these new ligands was also tested.