- 作者：Simona F. Shaitelman ; M.D. ; Ed.M.&lowast ; ; J. Ben Wilkinson ; M.D.&dagger ; ; Larry L. Kestin ; M.D.&lowast ; ; Hong Ye ; M.S.&dagger ; ; Neal S. Goldstein ; M.D.§ ; ; Alvaro A. Martinez ; M.D.&Dagger ; ; Frank A. Vicini ; M.D.&Dagger ; ; fvicini@pol.net
- 关键词：Ductal carcinoma in situ ; Breast cancer ; Young age ; Radiation therapy
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2012
- 期刊代码：136_03603016
- 类别：med
- 出版时间：1 July, 2012
- 卷：83
- 期：3
- 页码：e305-e312
- 文件大小：174 K
Purpose
To determine 20-year rates of local control and outcome-associated factors for ductal carcinoma in situ (DCIS) after breast-conserving therapy (BCT).Methods and Materials
All DCIS cases receiving BCT between 1980 and 1993 were reviewed. Patient demographics and pathologic factors were analyzed for effect on outcomes, including ipsilateral breast tumor recurrence (IBTR) and survival.
Results
One hundred forty-five cases were evaluated; the median follow-up time was 19.3 years. IBTR developed in 25 patients, for 5-, 10-, 15-, and 20-year actuarial rates of 9.9%, 12.2%, 13.7%, and 17.5%, respectively. One third of IBTRs were elsewhere failures, and 68%of IBTRs occurred <10 years after diagnosis. Young age and cancerization of lobules predicted for IBTR at <10 years, and increased slide involvement and atypical ductal hyperplasia were associated with IBTR at later time points.
Conclusions
Patients with DCIS treated with BCT have excellent long-term rates of local control. Predictors of IBTR vary over time, and the risk of recurrence seems highest within 10 to 12 years after diagnosis.