Lifestyle intervention, diabetes, and cardiovascular disease

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• 作者：Jaana Lindströ ; m ; Matti Uusitupa
• 关键词：FXR ; Decorin ; Smooth muscle cells ; Vascular ; Regulation
• 刊名：The Lancet
• 出版年：2008
• 期刊代码：182_01406736
• 类别：med
• 出版时间：24 May 2008-30 May 2008
• 卷：371
• 期：9626
• 页码：1731-1733
• 文件大小：162 K

摘要

In 1986, 577 adults with impaired glucose tolerance from 33 clinics in China were randomly assigned to either the control group or to one of three lifestyle intervention groups (diet, exercise, or diet plus exercise). Active intervention took place over 6 years until 1992. In 2006, study participants were followed-up to assess the long-term effect of the interventions. The primary outcomes were diabetes incidence, CVD incidence and mortality, and all-cause mortality.

ss="h4">Findings

Compared with control participants, those in the combined lifestyle intervention groups had a 51%lower incidence of diabetes (hazard rate ratio [HRR] 0·49; 95%CI 0·33–0·73) during the active intervention period and a 43%lower incidence (0·57; 0·41–0·81) over the 20 year period, controlled for age and clustering by clinic. The average annual incidence of diabetes was 7%for intervention participants versus 11%in control participants, with 20-year cumulative incidence of 80%in the intervention groups and 93%in the control group. Participants in the intervention group spent an average of 3·6 fewer years with diabetes than those in the control group. There was no significant difference between the intervention and control groups in the rate of first CVD events (HRR 0·98; 95%CI 0·71–1·37), CVD mortality (0·83; 0·48–1·40), and all-cause mortality (0·96; 0·65–1·41), but our study had limited statistical power to detect differences for these outcomes.

ss="h4">Interpretation

Group-based lifestyle interventions over 6 years can prevent or delay diabetes for up to 14 years after the active intervention. However, whether lifestyle intervention also leads to reduced CVD and mortality remains unclear.

ss="h4">Funding

Centers for Disease Control and Prevention, WHO, the China-Japan Friendship Hospital, and Da Qing First Hospital.