Single polymorphism nucleotide rs1333049 on chromosome 9p21 is associated with carotid plaques but not with common carotid intima-media thickness in older adults. A combined analysis of the Three-City and the EVA studies

详细信息	查看全文 | 推荐本文 |

• 作者：Matthieu Plichart^a ; ^b ; ^{matthieu.plichart@inserm.fr} ; Jean-Philippe Empana^a ; Jean-Charles Lambert^c ; Philippe Amouyel^c ; Laurence Tiret^d ; Luc Letenneur^e ; Claudine Berr^f ; Christophe Tzourio^g ; Pierre Ducimetiè ; re^h
• 关键词：Epidemiology ; Elderly ; Coronary heart disease ; Genetic ; Carotid ; Atherosclerosis ; Arteriosclerosis
• 刊名：Atherosclerosis
• 出版年：2012
• 期刊代码：28_00219150
• 类别：med
• 出版时间：May, 2012
• 卷：222
• 期：1
• 页码：187-190
• 文件大小：168 K

摘要

Objectives

To address the relationship of rs1333049, the 9p21 variant showing the strongest association with coronary heart disease (CHD), with carotid plaques and plaque-free common carotid artery intima-media thickness (CCA-IMT) in older adults from 2 French population-based cohorts.

Methods

We genotyped for rs1333049, 4097 CHD-free participants including 3191 aged 65-86 years from the Three-City (3C) Study and 906 aged 59-71 years from the Vascular Aging Study (EVA). Plaque-free mean CCA-IMT and the presence of carotid plaques were assessed.

Results

In multivariate analysis, each C allele copy of rs1333049 was associated with baseline carotid plaques (odds ratio (OR) = 1.24; 95%confidence interval (CI) = 1.13-1.36; p < 0.001) but not with baseline CCA-IMT (p = 0.19). Among the EVA participants, the C allele was associated with 4-year plaques progression (p = 0.04) but not with CCA-IMT progression.

Conclusion

The chromosome 9p21 locus might influence CHD risk through carotid plaques development.