- 作者：Jose Carlos Aré ; valo Lorido ; Juana Carretero Gó ; mez<sup> ; sup><sup>juanicarretero@gmail.comsup>
- 关键词：Ictus isqué ; mico ; Infarto aterotrombó ; tico ; Proteí ; na C reactiva
- 刊名：Medicina Cl铆nica
- 出版年：2009
- 期刊代码：pca254_00257753
- 类别：med
- 出版时间：10 October 2009
- 卷：133
- 期：13
- 页码：496-500
- 文件大小：152 K
ss="h4">Background and objective
We aimed to investigate the relation between values of C-reactive protein (CRP) and carotid artery intima-media thickness (IMT) in patients with atherothrombotic ischemic stroke.
ss="h4">Patients and method
One hundred and thirty five patients within 48 h after index ischemic stroke were included. CRP levels were obtained at this time and a carotid ultrasonography was performed. Neurological and functional disability were evaluated, and all patients underwent a cardiovascular risk stratification. Patients were divided in three groups according to the tertiles of they IMT distribution. We adjusted for the possible confounding effect using a multivariate logistic model.
ss="h4">Results
Forty three in-patients were classified into group 1 (IMT between 0.7 and 1.1 millimetres), 43 into group 2 (IMT between 1.2 and 1.5 millimetres) and 49 into group 3 (IMT higher of 1.6 millimetres). We found a significant elevation of CRP levels at different groups (p<0.0008), with medians by group of 0.3, 0.4 and 1.5 mg/dl respectively. Likewise, we found significant differences by group in functional disability (p<0.03) and in vascular risk stratification (p<0.02).
ss="h4">Conclusions
CRP is a marker of increased IMT in patients with atherothrombotic ischemic stroke. A cutoff point of 1.5 mg/dl for CRP provided a greater IMT and a worse outcome in functional disability as cardiovascular risk. Therefore, this group requires a more intensive treatment in secondary prevention.