Hybrid nanostructured drug carrier with tunable and controlled drug release
- 作者：D. Depan ; R.D.K. Misra ; dmisra@louisiana.edu
- 关键词：Carbon nanotubes ; Nanohybrid structure ; Doxorubicin ; Copolymer ; Drug release
- 刊名：Materials Science and Engineering ; C
- 出版年：2012
- 期刊代码：63_09284931
- 类别：ms
- 出版时间：1 August, 2012
- 卷：32
- 期：6
- 页码：1704-1709
- 文件大小：971 K
摘要
We describe here a transformative approach to synthesize a hybrid nanostructured drug carrier that exhibits the characteristics of controlled drug release. The synthesis of the nanohybrid architecture involved two steps. The first step involved direct crystallization of biocompatible copolymer along the long axis of the carbon nanotubes (CNTs), followed by the second step of attachment of drug molecule to the polymer via hydrogen bonding. The extraordinary inorganic-organic hybrid architecture exhibited high drug loading ability and is physically stable even under extreme conditions of acidic media and ultrasonic irradiation. The temperature and pH sensitive characteristics of the hybrid drug carrier and high drug loading ability merit its consideration as a promising carrier and utilization of the fundamental aspects used for synthesis of other promising drug carriers. The higher drug release response during the application of ultrasonic frequency is ascribed to a cavitation-type process in which the acoustic bubbles nucleate and collapse releasing the drug. Furthermore, the study underscores the potential of uniquely combining CNTs and biopolymers for drug delivery.