Drug eluting sutures: A model for in vivo estimations
- 作者：Tommaso Casalini ; Maurizio Masi ; Giuseppe Perale ; giuseppe.perale@polimi.it
- 关键词：Mathematical modeling ; Drug delivery ; Pharmaceuticals ; Biopolymers ; Suture threads
- 刊名：International Journal of Pharmaceutics
- 出版年：2012
- 期刊代码：24_03785173
- 类别：pha
- 出版时间：15 June, 2012
- 卷：429
- 期：1-2
- 页码：148-157
- 文件大小：667 K
摘要
This work is focused on the development of a transient 1-dimension model to describe drug release from a bioresorbable suture thread in a living tissue and the pharmacologic behavior of the active substance being delivered from the device into the tissue. The model is based on fundamental conservation laws, represented by mass balances, being the thread degradation described through population balances and involving detailed hydrolysis kinetics. Monomer, water and drug diffusion are assumed as Fickian, and the increasing of diffusion coefficient is expressed with the 鈥渇ree volume鈥?theory. Drug behavior in tissue is described with a 鈥渄iffusion and reaction鈥?approach. The model leads to a system of partial differential equations solved by applying the method of lines and then numerically integrated. Simulations allowed to estimate release dynamics and drug behavior in tissue and to obtain spatial and temporal profiles of drug in tissue. Moreover, phase diagrams, which show drug effect in time and space, are here introduced for the first time.