Ultrasmall superparamagnetic iron oxides enhanced MR imaging in rats with experimentally induced endometriosis

详细信息	查看全文 | 推荐本文 |

• 作者：Hyun Jung Lee^a ; Hui Joong Lee^b ; ^{knuhrad@yahoo.co.kr} ; Jong Min Lee^b ; Yongmin Chang^b ; ^c ; Seung Tae Woo^d
• 关键词：Experimental ; Endometriosis ; Ultrasmall superparamagnetic iron oxides magnetic resonance imaging
• 刊名：Magnetic Resonance Imaging
• 出版年：2012
• 期刊代码：188_0730725x
• 类别：med
• 出版时间：July, 2012
• 卷：30
• 期：6
• 页码：860-868
• 文件大小：1368 K

摘要

Purpose

The purpose of our study was to evaluate the feasibility of magnetic resonance imaging (MRI) using ultrasmall superparamagnetic iron oxides (USPIO) in the detection of experimentally induced endometriosis.

Materials and methods

Endometriosis was surgically induced in rats by transplanting an autologous fragment of uterine tissue onto the inner surface of the abdominal wall, the posterior surface of the uterine body and the arterial cascades of the small intestines adjacent to mesenteric blood vessels. Six weeks later, MRI using Gd-DTPA and USPIO was performed for the evaluation of the ectopic uterine tissue (EUT). A scoring system was developed for image interpretation (0=absence, 1=probably absence, 2=probably presence and 3=presence). We defined MR index (MRIx) as the sum of T1-weighted and enhanced T1-weighted and T2-weighted image scores, and USPIO MRIx (MRIx^+USPIO) as the MRIx score plus the score of USPIO-enhanced T2-weighted image.

Results

The MRIx^+USPIO was also higher in the successfully autotransplanted group than in the failed group (6.19卤1.72 versus 3.94卤1.20, P<.001). There was also a significant linear relationship between MRIx^+USPIO and pathologic status (R²=0.494, P<.001). Thirty-one (64.6%) of the 48 implanted uterine tissues were histologically confirmed on pathologic review. The area of MRIx and MRIx^+USPIO in the detection of EUT more than 3 mm in size was 0.739 and 0.913, respectively.

Conclusion

Our results suggest that USPIO-enhanced MRI could be a novel diagnostic tool for diagnosis in experimentally induced peritoneal endometriosis.