Inactivation of p16 by CpG hypermethylation in renal cell carcinoma
- 作者：Marta Vidaurreta ; M. Luisa Maestro ; M. Teresa Sanz-Casla ; Carmen Maestro ; Sara Rafael ; Silvia Veganzones ; Jesus Moreno ; Julia Blanco ; Angel Silmi ; Manuel Arroyo
- 关键词：Cancer ; Kidney ; p16 promoter methylation ; p16 protein ; Prognosis
- 刊名：Urologic Oncology ; Seminars and Original Investigations
- 出版年：2008
- 期刊代码：266_10781439
- 类别：med
- 出版时间：May-June 2008
- 卷：26
- 期：3
- 页码：239-245
- 文件大小：111 K
摘要
Renal carcinoma develops as a consequence of the accumulation of several genetic aberrations. Alterations in the p16 gene have been described in many tumors. Methylation of its promoter in CpG islands is the most common mechanism of inactivation of this gene. The aim of this study was to establish whether p16 gene methylation leads to a loss of the encoded protein in 57 patients with renal carcinoma, and if this aberration has any value in predicting disease progression in these patients.